Grants & Opportunities

The Role of Lck/CD8 Association in Negatively Regulating T cell Activation. This proposal aims to advance our fundamental understanding of how T cell recognition of antigens translates into a T cell activating signal. The proposal will establish whether the major T cell coreceptor also acts as a negative regulator of T cell activation in vivo when antigen recognition is unorthodox. It will also determine whether certain subsets of T cells naturally lack coreceptors in order to facilitate unorthodox antigen recognition. Thus, the proposal will significantly advance our understanding of, and establish new paradigms around, the regulation of T cell activation. Expected long term benefits outside the scope of this proposal include improved immunotherapies and vaccines designed to elicit or suppress T cell responses.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Nicole La Gruta

A next-generation whole parasite bovine Babesia vaccine. . In Australia, Babesia parasites cause most of the severe and often fatal cases of cattle-tick fever, a globally significant tick-borne disease. It can be prevented by a live-attenuated parasite vaccine which has critical limitations of a 4-day shelf-life and risk of severe disease if administered to adult cattle. This project aims to evaluate in cattle a novel whole parasite Babesia bovis vaccine that cannot cause disease and can be preserved as an off-the-shelf product without losing efficacy. The expected outcome is a significantly improved vaccine for a major infectious disease that affects primary food production. As the disease imposes a major economic burden, it will have great benefit for the Australian livestock industry. . Scheme: Discovery Projects. Field: 3003 - Animal Production. Lead: A/Prof Danielle Stanisic

Resilient design of energy pile foundations toward zero carbon buildings. This project aims to investigate the complex thermo-hydro mechanical interactions affecting the effectiveness of energy pile foundations for improved energy efficiency of new buildings. Using cutting-edge micro to field-scale methods, this project expects to underpin the development of experimentally validated predictions of the geotechnical performance of energy piles. Expected outcomes of this project are the establishment of new approaches to improve the resilient design of energy pile foundations, provision of new recommendations for their design and increased integration for zero carbon buildings. These outcomes will contribute significantly toward strategies to decarbonise energy systems in buildings to meet carbon neutrality goals.. Scheme: Discovery Projects. Field: 4005 - Civil Engineering. Lead: Prof Abdelmalek Bouazza

Transforming Australian bio-based industries through multiscale modelling. Agricultural and forestry biomass can be converted into feedstocks for production of biofuels and biomaterials via synthetic biology. A key challenge is the complex biomass microstructure renders it highly resistant to conversion, and pretreatment is crucial for enhancing process efficiency. Micro-CT imaging will enable particle characterisation and identification of changes in the fibre composition during pretreatment. This information will be used to create a virtual biomass particle model for an in silico investigation to inform optimal process design. The framework will transform the way biomass is processed, contributing to the growth of the Australian bio-manufacturing industry by making it more productive, profitable and sustainable.. Scheme: Discovery Projects. Field: 4903 - Numerical and Computational Mathematics. Lead: Em/Prof Ian Turner

Biomass-derived Carbon Dots Enable Flexible, On-Demand Hydrogen Delivery . Methanol is a promising liquid hydrogen carrier for long distance H2 transportation and exportation, because it is rich in hydrogen content, cheap, recyclable between methanol-formaldehyde and easier to manufacture from renewable resources including biomass waste. The critical bottleneck in adopting methanol as the carrier is the demanding dehydrogenation process. The project aims to create a new class of photocatalyst based on biomass-derived carbon nanodots grown on transition metal (di)chalcogenide nanosheets that can effectively enable a light-controlled methanol H2 release of desired quantity. The key outcomes will be a new class of photocatalysts and flexible, on-demand hydrogen delivery technology for liquid hydrogen carriers.. Scheme: Discovery Projects. Field: 4004 - Chemical Engineering. Lead: Prof Qin Li

Hybridisation leading to lost sex: genomic and experimental insights. The project intends to apply advanced genomics to two classic Australian systems and quantitative genetics to one to address long-standing questions about why asexual reproduction is rare. It aims to test for rapid changes in genomes accompanying hybrid-origins of asexuals and whether this new diversity enables their ongoing evolution. The significance is that support for this hypothesis would challenge current theory for why sex is so common. The expected outcome is to understand how variation is generated in natural populations with different ways of reproducing. Benefits would include significant contributions to global science, evolutionary training and potential applications in using hybridisation to manage threatened species or pests.. Scheme: Discovery Projects. Field: 3104 - Evolutionary Biology. Lead: Prof Craig Moritz

The viral fusosome: a modular machinery for cargo delivery to target cells. The delivery of proteins, RNA and DNA into cells is a critical process in normal cellular biology, virus infection and biotechnology applications such as gene editing. Enveloped viruses achieve this maneuver with exquisite efficiency and specificity using a complex machinery mediating their fusion with cellular membranes for stealth genome delivery. Remarkably, all characterised viral fusion proteins belong to only 3 classes defined >16 years ago and sharing surprisingly conserved mechanisms. We identified a novel class of fusion proteins with unique architecture in ubiquitous insect viruses. The Project will elucidate the structural and functional hallmarks of this fusion machinery providing a platform for its engineering.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Fasseli Coulibaly

Connecting ocean tides to the large-scale ocean circulation. This project aims to investigate the impact of tides on the ocean circulation and future climate change by combining new theory with next-generation numerical ocean models. The expected outcomes include ocean model configurations that will improve estimates of key processes affected by tides, such as Antarctic ice shelf melt rates, ocean warming and the ocean's overturning circulation. The project is thus anticipated to provide significant benefits in predicting future climate change, sea level rise, coastal erosion and marine heatwaves. Furthermore, it will enable the Australian and global communities to better target conservation and mitigation efforts, and thus reduce the environmental, social and economic impact of climate change.. Scheme: Discovery Projects. Field: 3708 - Oceanography. Lead: Dr Callum Shakespeare

Mapping & Harnessing Public Mistrust: Constitutional Values Survey 2023-27. Declining public trust is well recognised as a problem of democratic government, including in Australia. However solutions are more elusive, confounded by the reality that mistrust and distrust play not just negative, but positive roles in our existing political and constitutional traditions. This project aims to be the first to comprehensively map the positive values of mistrust in citizen political attitudes and experience, building on previous Constitutional Values Surveys (2008-21) to test new measures of the content of trust including a first-ever longitudinal study of changing trust over time. The results will inform concrete solutions to three key policy reform dilemmas, providing better answers for sustaining public trust overall. . Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Prof Alexander Brown

Veteran suicide: investigating the historical and social dimensions . This project aims to address veteran suicide by conducting an historical and cultural analysis of the ways government, the military and the community have understood, governed, and serviced veterans from 1914-present. This project will generate new knowledge, moving beyond orthodox medical and cultural assessments to explore wider historical, cultural and sociological relations of veteran suicide, including civil military relations, and the influence of the veteran sector and families and community. The project will develop an innovative survey that will form the foundation of a longitudinal social health and wellbeing dataset on veterans, and contribute to policy and service provision to reduce veteran suicide and improve their wellbeing.. Scheme: Discovery Projects. Field: 4410 - Sociology. Lead: Prof Ben Wadham

Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that provide these novel materials with clear potential as electroactive materials with applications in various nanoelectronics devices. Developing a fundamental understanding of charge transport properties and potential device applications will open up a new field of research in advanced optoelectronic technology. . Scheme: Discovery Projects. Field: 4016 - Materials Engineering. Lead: Prof Prashant Sonar

Dynamic Microcages for Cells: Advanced Tools to Interrogate Cell Mechanics. This project aims to develop a suite of movable micro/nanostructures with integrated mechanical and biological sensors, which will be interfaced with cells to investigate how those cells respond to their surrounding physical environment. Expected outcomes are new technologies in micro/nanofabrication, sensing, and advanced imaging, and deep understanding of the biological processes that control tissue formation and repair. These outcomes would impact how 3D microsystems are developed and applied, informing the design of advanced in-vitro cell culture systems. Significant benefits are expected in 3D nano-microengineering, and in generating new knowledge underpinning future advances in stem cell and tissue engineering technologies.. Scheme: Discovery Projects. Field: 4018 - Nanotechnology. Lead: Prof Nicolas Voelcker

A platform technology for developing mesoporous polymer particles. This project aims to apply polymerisation-induced self-assembly process to develop triggerable mesoporous polymer particles as advanced functional materials for various applications. By combining this scalable process and automated synthesis technique, mesoporous polymer particles that can disassemble in response to external triggers, such as light, redox conditions and enzymes, will be developed. The knowledge gained from this research will allow researchers to fully understand the formation and evolution mechanism of inverse bicontinuous structures observed in nature and produced in synthetic labs. Importantly, the applications of these novel stimuli-responsive particles as nano-carriers and templating scaffolds will be investigated.. Scheme: Discovery Projects. Field: 3403 - Macromolecular and Materials Chemistry. Lead: Prof San Thang

Political Representation in Indonesia. The project aims to understand political representation in Indonesia, asking how far politicians resemble voters in both their policy views and backgrounds (gender, religion, education etc.) It will generate new knowledge on a major potential source of fragility in the world’s third largest democracy, and pioneer a new multi-method approach for explaining how representation varies. Expected outcomes include a new framework that extends analysis of representation to illiberal democracies, and a tranche of public data on Indonesia for cross-national comparisons. Benefits will include a new set of analytical tools to help policy makers in Australia and the region assess sources of weakness in representative institutions in illiberal settings.. Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Prof Edward Aspinall

The Benefits of Utilising Visual-Spatial Representations of Numbers . The aim of this project is to investigate how visual-spatial representations of numbers enhance practice to promote the use of retrieval-based over counting-based strategies for children learning early arithmetic. About one-third of Australian children stay reliant on counting strategies for basic arithmetic, despite these being associated with lower achievement in mathematics in later years. Expected outcomes of this project are new understandings of how problem-answer associations can be strengthened in memory and the development of tools to promote retrieval-based strategies. Potential benefits include children who are better prepared to take on higher-level mathematics in secondary school and, subsequently, more numerate citizens. . Scheme: Discovery Projects. Field: 3904 - Specialist Studies In Education. Lead: A/Prof Sarah Hopkins

Understanding bone structure evolution using machine learning. Bone remodeling is the ancient process of bone resorption and formation that optimises material properties and has led to evolution of terrestrial vertebrates. To date it is not understood how remodeling achieves tuning of bone material. This proposal aims to develop a machine learning based approach, linking computational modeling and imaging to address this problem. Intended outcomes are development of a multiscale model of remodeling and machine learning algorithms for image analysis. This approach will help establish a structural-functional link between remodeling and bone material optimisation which ultimately provides significant benefits for bone tissue engineering, fracture healing and improved therapies for osteoporosis. . Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Peter Pivonka

Building A Better Built Environment for Older Australian's Ageing-in-place. Most older Australians prefer to age in place after their retirement. This project aims to understand how the built environment as a comprehensive system supports (or hinders) their ageing-in-place given that the existing Australian built environment fails to meet older Australians' requirements for independent living. This project expects to generate new knowledge in the area of ageing-friendly communities using Bayesian Network analysis and interactive design charrettes. Expected outcomes include an evidence-based Bayesian network model that determines how the built environment affects independent living in the community and design innovation and guidelines to improve the built environment design for older Australians' ageing-in-place.. Scheme: Discovery Projects. Field: 3302 - Building. Lead: Prof Bo Xia

Exploiting Geometries of Learning for Fast, Adaptive and Robust AI. This project aims to uniquely exploit geometric manifolds in deep learning to advance the frontier of Artificial Intelligence (AI) research and applications in cybersecurity and general cognitive tasks. It expects to develop new theories, algorithms, tools, and technologies for machine learning systems that are fast, adaptive, lifelong and robust, even with limited supervision. Expected outcomes will enhance Australia's capability and competitiveness in AI, and deliver robust and trustworthy learning technology. The project should provide significant benefits not only in advancing scientific and translational knowledge but also in accelerating AI innovations, safeguarding cyberspace, and reducing the burden on defence expenses in Australia.. Scheme: Discovery Projects. Field: 4611 - Machine Learning. Lead: Prof Dinh Phung

Global integration of microbial community and climate data. Microbial communities in the environment control the cycling of carbon and nutrients on Earth, but climate models do not directly incorporate microbial inputs. This interdisciplinary project will link planetary-scale climate modelling data with novel large-scale microbial community analysis, using climate information to provide insight into the fantastic diversity of microbial processes on our planet. The interdisciplinary approach will inform the next generation of climate models and better predict our future climate’s feedbacks. Conversely, it will make progress on the grand challenge of understanding microbial community function by enabling microbial ecology to be treated as a data-intensive machine learning problem.. Scheme: Discovery Projects. Field: 3107 - Microbiology. Lead: A/Prof Benjamin Woodcroft

The first English speakers in their own words. This project aims to produce the first comprehensive study of the attitudes in the earliest English literature. The project expects to generate new knowledge about the first English speakers, what issues mattered most to them and how broad the range of attitudes was. Expected outcomes of this project include new approaches to studying the past, enhanced international collaborations and a public access to the project's data through an open access digital resource. This should provide significant benefits in terms of our understanding of the past and how it shapes attitudes in contemporary Australia. . Scheme: Discovery Projects. Field: 4705 - Literary Studies. Lead: A/Prof Erin Sebo

Efficient and secure data integrity auditing on cloud. Data auditing presents a promising way for verifying user data integrity on cloud, i.e., whether user privacy sensitive data such as identity information on cloud is modified or lost. Current auditing approaches lack sufficient efficiency and security. This results in that they cannot provide timely warning and precaution on potential data loss threats. This project aims to systematically investigate this significant challenge and expects to establish innovative research and solutions for enabling efficient and secure data integrity auditing on cloud. The project outcomes will help to safeguard Australian community in fast-growing cyber world, and benefit to fast-growing user privacy sensitive data hosting and applications on cloud.. Scheme: Discovery Projects. Field: 4604 - Cybersecurity and Privacy. Lead: Prof Jinjun Chen

Tackling Crystal Methamphetamine Supply in Rural and Regional Australia. This project tackles one of the leading drug policy and organised crime issues in Australia, namely the increased availability of crystal methamphetamine (ice) in rural and regional communities. The first study of its kind nationally, it will use an innovative combination of qualitative and quantitative methods across six communities in three states to uncover how ice infiltrates regional communities, the drivers and mechanisms and impacts thereof. Expected outcomes include a roadmap to reduce supply and harms, strengthened communities and enhanced international collaborations. With ice use and supply costing the Australian government $5 billion per year, the project stands to provide significant social, public health and economic benefits.. Scheme: Discovery Projects. Field: 4402 - Criminology. Lead: A/Prof Caitlin Hughes

Ultra-Fast and Secure Terahertz Communications for 6G Wireless Systems. This project aims to develop new theories and signal processing solutions for the cutting-edge technology of terahertz communications to enable the revolutionary sixth-generation wireless systems, by exploring and optimising the inherent benefits of the terahertz band. Anticipated outcomes are new analytical tools and practical guidelines for designing ultra-fast and secure wireless transmission at an unprecedented speed up to terabits per second (Tbps). This enables various emerging applications, such as holographic telepresence, Tbps WiFi and Tbps wireless data centres, to drive transformation in the telecommunications sector, boost industry productivity and support our intelligent information society in the 2030s.. Scheme: Discovery Projects. Field: 4006 - Communications Engineering. Lead: Prof Nan Yang

Co-designing and co-evaluating technology experiences in residential care . This project aims for meaningful experiences and skill development by older adults living in residential care using technologies. Based on the interests, abilities and everyday context it is important to introduce technologies in a way that supports agency and confidence. Through co-design and co-evaluation we develop a process to explore technology choices and learning. We will (i) generate guidelines for introducing technology, (ii) develop methods and success criteria for the co-evaluation of the process, and (iii) gain in-depth understandings of how facilitation and technology uptake are enacted in a range of residential settings. Older adults in residential care will benefit through increased digital equity and technology adoption. . Scheme: Discovery Projects. Field: 4608 - Human-Centred Computing. Lead: Prof Sonja Pedell

A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Yi-Chin Toh