Grants & Opportunities

Imaging mammalian organogenesis with adaptive optics. Optical and computational barriers to analysing cell movement have limited our understanding of mammalian organogenesis. We have built a super-resolution spinning disk confocal microscope with adaptive optics and developed machine learning-based image processing and cell segmentation workflows to overcome these long-standing barriers. We propose to combine these cutting-edge live imaging and analysis approaches to characterise the role of cell movement in mammalian organ formation and develop advanced cell segmentation and tracking methods for use in the scientific community. We anticipate this project will generate fundamental insights into how cells interact to build complex organs.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Dr Alexander Combes

Why is (re)development hot?: Measuring cumulative heat in Australian cities. Incremental (re)development of Australia’s residential areas occurs piecemeal, with varied planning oversight, and results in potentially harmful cumulative warming. This project aims to causally identify the warming effect of residential (re)development and investigate the impact of planning policies that control changes in the built form associated with increased heat exposure. Using large geospatial datasets and a quasi-experimental research design, warming in Australia’s suburbs over the past decade at the micro (street canyon)- and neighbourhood-scales, will be attributed to (re)development types and ‘fissures’ in policy to inform climate resilient planning. . Scheme: Discovery Projects. Field: 3304 - Urban and Regional Planning. Lead: A/Prof Bryan Boruff

Novel tools for dating explosive volcanic eruptions in the critical window. This project will develop novel dating methods necessary for precise reconstruction of the eruption histories of super-volcanoes in the Asia-Pacific region over the last million years. The project outcomes will provide better models for predicting super-eruptions, thereby informing global climate change research, urban planning, and transport and telecommunications infrastructure engineering. Results will also improve existing volcanic risk models used by insurers to quantify volcanic risks and calculate expected losses from volcanic eruptions, and greatly improve our ability to use eruption deposits as time markers for important events in human evolution.. Scheme: Discovery Projects. Field: 3705 - Geology. Lead: A/Prof Martin Danisik

Online anti-racism for Australia. Harmful manifestations of online racism are increasing. The neo-liberal assumption is that social media users and user groups can be responsiblised to disrupt online racism. This project analyses a subset of online anti-racism campaigns. The review provides the material to test effectiveness, using surveys. The survey findings will identify the ingredients for effective, safe and efficient online anti-racism intervention. An online anti-racism program will be developed, implemented and evaluated. The development of guidelines for online anti-racism will overtly address the challenges and risks of action in this environment where regulation is so heavily contested.. Scheme: Discovery Projects. Field: 4410 - Sociology. Lead: Prof Kevin Dunn

Discovery and directed evolution of small molecule biosensors. This project aims to address the need for novel small molecule biosensing capability in diverse fields including food and wine production, environmental monitoring, biocatalysis, and diagnostics using a synthetic biology approach. The significance of this work is the development of new biosensors by a strong interdisciplinary team contributing bioinformatics to identify new biosensors, innovative protein engineering approaches, and cutting-edge directed evolution methodologies. Intended outcomes include enhanced institutional capacity for interdisciplinary collaboration; discovery of fundamentally important bacterial sensors; and development of synthetic regulatory circuits enabling outgrowth of non-biological biocatalysis industries.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Fiona Whelan

China’s changing internal migration: patterns, causes, policy implications. China’s massive internal migration is no longer simply rural–urban and circular but highly diversified. The project aims to unravel that transition: its patterns, causes, and effects. Using 2020 census data and major longitudinal datasets, a China variant of Zelinsky’s classic mobility transition theory will be developed and deployed to identify underlying mechanisms. Among expected outcomes are powerful methods for assessing spatio-temporal migration patterns and causes, applicable to many economies especially in the Asia–Pacific. Benefits should include a new evidence base for migration and related urban–rural policy in China; and for Australia, policy inputs to improve prosperity through better relations with our biggest trading partner.. Scheme: Discovery Projects. Field: 4403 - Demography. Lead: A/Prof Yan Tan

Mapping Australians' Media Use and Civic Attitudes. This project would address the need to better understand how patterns of media consumption in Australia are correlated with knowledge about current events, civic attitudes, and political polarisation. It would provide the first empirical study of the relationship in a fast changing media environment between the ways Australians access information about the news, their knowledge of current events, and their expressed civic values. Significant benefits include a greater understanding of how Australians use the media to stay informed and how these practices shape values of crucial concern to democratic participation and deliberation. The findings would be shared through white papers, academic and public-facing publications, and workshops.. Scheme: Discovery Projects. Field: 4701 - Communication and Media Studies. Lead: Prof Mark Andrejevic

Beautiful strings. This project aims to carry out several key experimental measurements, in tandem with substantial theoretical work, to improve the understanding and physical modelling of processes involving b quarks, also called beauty quarks, which are of intense current interest for experiments across the globe. Key theoretical innovations include novel treatments of electromagnetic corrections, novel theoretical formulations of the dominant physical paradigm of string fragmentation, and optimisations of key associated algorithms to enable new applications of broad relevance. Experimental measurements will be carried out to validate the new theoretical developments and use them to minimise theoretical uncertainties.. Scheme: Discovery Projects. Field: 5107 - Particle and High Energy Physics. Lead: Prof Peter Skands

Australian clays as raw materials of slow-release phosphate fertiliser. Phosphorus (P) fertiliser input in Australia is a significant problem for its inefficient plant uptake, leaching to natural water bodies and stocking of insoluble P in soil. The project aims to develop activated clays using Australian raw clay minerals to formulate effective slow-release phosphate (P) fertilisers (SRF) and delivery material for P-solubilising bacteria. Composite of these will supply P controllably even amid environmental fluctuations but when a plant needs as it grows. Development of multifunctional, nontoxic and plant growth-driven P fertiliser would benefit improve soil fertility in a sustainable way where efficiency of P input is maximised with a minimised environmental burden.. Scheme: Discovery Projects. Field: 4016 - Materials Engineering. Lead: Prof Ravendra (Ravi) Naidu

The Material Science of Biomimetic Soft Network Composites. Nature combines stiff and strong collagen fibres intertwined within a weak polymer matrix of proteoglycans into soft tissues with outstanding mechanical durability and biological properties. We converge a biomimetic design strategy inspired in the architecture of natural soft tissues and a novel additive manufacturing technology termed melt electrowriting (MEW) to manufacture advanced biomimetic soft network composites (BSNC). The SNCs are composed of a weak polymer matrix and a MEW reinforcing fibrous phase printed at the nanometre scale, containing patterns mimicking the natural tissue architectures. Advanced computational tools are applied for the rational design of the SNC while reducing costs and times associated to experimental work.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Dietmar W. Hutmacher

Hiding in Plain Sight: 'Associated Entities' and Australian Democracy. Associated Entities (AEs) are organisations that are formally linked to political parties. This project aims to examine how AEs interact with Australian democracy by investigating their impact on elections, the law, and party system dynamics. This project expects to generate new knowledge about the impact of these nearly 200 key political actors, with a particular focus on how they are able to elude significant scrutiny of their activities. Expected outcomes include a new typology of AEs, a new financial index to measure their impact, and proposals to improve their regulation. The key benefits generated include: a strengthened campaign finance regime, and enhanced transparency and integrity to Australia's democracy.. Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Dr Rob Manwaring

Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.. Scheme: Discovery Projects. Field: 3108 - Plant Biology. Lead: Prof Matthew Tucker

The Role of Lck/CD8 Association in Negatively Regulating T cell Activation. This proposal aims to advance our fundamental understanding of how T cell recognition of antigens translates into a T cell activating signal. The proposal will establish whether the major T cell coreceptor also acts as a negative regulator of T cell activation in vivo when antigen recognition is unorthodox. It will also determine whether certain subsets of T cells naturally lack coreceptors in order to facilitate unorthodox antigen recognition. Thus, the proposal will significantly advance our understanding of, and establish new paradigms around, the regulation of T cell activation. Expected long term benefits outside the scope of this proposal include improved immunotherapies and vaccines designed to elicit or suppress T cell responses.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Nicole La Gruta

A next-generation whole parasite bovine Babesia vaccine. . In Australia, Babesia parasites cause most of the severe and often fatal cases of cattle-tick fever, a globally significant tick-borne disease. It can be prevented by a live-attenuated parasite vaccine which has critical limitations of a 4-day shelf-life and risk of severe disease if administered to adult cattle. This project aims to evaluate in cattle a novel whole parasite Babesia bovis vaccine that cannot cause disease and can be preserved as an off-the-shelf product without losing efficacy. The expected outcome is a significantly improved vaccine for a major infectious disease that affects primary food production. As the disease imposes a major economic burden, it will have great benefit for the Australian livestock industry. . Scheme: Discovery Projects. Field: 3003 - Animal Production. Lead: A/Prof Danielle Stanisic

Resilient design of energy pile foundations toward zero carbon buildings. This project aims to investigate the complex thermo-hydro mechanical interactions affecting the effectiveness of energy pile foundations for improved energy efficiency of new buildings. Using cutting-edge micro to field-scale methods, this project expects to underpin the development of experimentally validated predictions of the geotechnical performance of energy piles. Expected outcomes of this project are the establishment of new approaches to improve the resilient design of energy pile foundations, provision of new recommendations for their design and increased integration for zero carbon buildings. These outcomes will contribute significantly toward strategies to decarbonise energy systems in buildings to meet carbon neutrality goals.. Scheme: Discovery Projects. Field: 4005 - Civil Engineering. Lead: Prof Abdelmalek Bouazza

Transforming Australian bio-based industries through multiscale modelling. Agricultural and forestry biomass can be converted into feedstocks for production of biofuels and biomaterials via synthetic biology. A key challenge is the complex biomass microstructure renders it highly resistant to conversion, and pretreatment is crucial for enhancing process efficiency. Micro-CT imaging will enable particle characterisation and identification of changes in the fibre composition during pretreatment. This information will be used to create a virtual biomass particle model for an in silico investigation to inform optimal process design. The framework will transform the way biomass is processed, contributing to the growth of the Australian bio-manufacturing industry by making it more productive, profitable and sustainable.. Scheme: Discovery Projects. Field: 4903 - Numerical and Computational Mathematics. Lead: Em/Prof Ian Turner

Biomass-derived Carbon Dots Enable Flexible, On-Demand Hydrogen Delivery . Methanol is a promising liquid hydrogen carrier for long distance H2 transportation and exportation, because it is rich in hydrogen content, cheap, recyclable between methanol-formaldehyde and easier to manufacture from renewable resources including biomass waste. The critical bottleneck in adopting methanol as the carrier is the demanding dehydrogenation process. The project aims to create a new class of photocatalyst based on biomass-derived carbon nanodots grown on transition metal (di)chalcogenide nanosheets that can effectively enable a light-controlled methanol H2 release of desired quantity. The key outcomes will be a new class of photocatalysts and flexible, on-demand hydrogen delivery technology for liquid hydrogen carriers.. Scheme: Discovery Projects. Field: 4004 - Chemical Engineering. Lead: Prof Qin Li

To what extent does Australian food policy consider its health impact. This research will examine how public policies relating to food can be made healthier. The diet of Australians currently contributes to high rates of disease including diabetes, heart disease and the underlying issue of obesity. It will examine Australian agriculture and food processing, manufacturing and marketing and the environmental impacts of these sectors. The research will analyse policy documents and interview key people involved in each sector to determine their views on the ways in which our food supply affects our health. It will result in policy recommendations advising how the Australian food sector can be made more supportive of health and equity. Policy makers will be engaged with our findings through a Food Policy Summit. . Scheme: Discovery Projects. Field: 4206 - Public Health. Lead: Prof Frances Baum

Hybridisation leading to lost sex: genomic and experimental insights. The project intends to apply advanced genomics to two classic Australian systems and quantitative genetics to one to address long-standing questions about why asexual reproduction is rare. It aims to test for rapid changes in genomes accompanying hybrid-origins of asexuals and whether this new diversity enables their ongoing evolution. The significance is that support for this hypothesis would challenge current theory for why sex is so common. The expected outcome is to understand how variation is generated in natural populations with different ways of reproducing. Benefits would include significant contributions to global science, evolutionary training and potential applications in using hybridisation to manage threatened species or pests.. Scheme: Discovery Projects. Field: 3104 - Evolutionary Biology. Lead: Prof Craig Moritz

Languages of Barrier Islands, Sumatra: Description, History and Typology. This project aims to investigate endangered languages of the Asia-Pacific via four undocumented languages in the Barrier Islands, Indonesia. New knowledge will be generated into the languages, cultures and societies of the region on an unprecedented scale, and be made freely available to the public. New data will uncover past migration patterns in Southeast Asia, advance language theory (such as linguistic typology and language change), and support the computational modelling of Austronesian for future language technologies. Connections with Indonesian institutions will strengthen Australia’s regional engagement, and support language revitalisation and maintenance among minority communities for the preservation of their culture and history.. Scheme: Discovery Projects. Field: 4704 - Linguistics. Lead: Prof I Wayan Arka

Responsive Metal-organic Framework Glass Membranes for Molecular Sieving. Metal-organic frameworks are an important category of microporous materials, showing extraordinary structural and chemical diversities. The recent discovery of their melting behaviours endows these materials with high processability, enabling the transformation of crystal powders into mechanically durable microporous bulk glasses for device assembly. This project aims to understand the melting and modification mechanism, and to incorporate responsive moieties to the glass. It further aims to realise switchable membrane separation for gas mixtures. This project is expected to enhance the understanding and application of these emerging glass materials and promote Australia’s capability in value-added manufacturing of metal minerals.. Scheme: Discovery Projects. Field: 4016 - Materials Engineering. Lead: A/Prof Jingwei Hou

The viral fusosome: a modular machinery for cargo delivery to target cells. The delivery of proteins, RNA and DNA into cells is a critical process in normal cellular biology, virus infection and biotechnology applications such as gene editing. Enveloped viruses achieve this maneuver with exquisite efficiency and specificity using a complex machinery mediating their fusion with cellular membranes for stealth genome delivery. Remarkably, all characterised viral fusion proteins belong to only 3 classes defined >16 years ago and sharing surprisingly conserved mechanisms. We identified a novel class of fusion proteins with unique architecture in ubiquitous insect viruses. The Project will elucidate the structural and functional hallmarks of this fusion machinery providing a platform for its engineering.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Fasseli Coulibaly

Connecting ocean tides to the large-scale ocean circulation. This project aims to investigate the impact of tides on the ocean circulation and future climate change by combining new theory with next-generation numerical ocean models. The expected outcomes include ocean model configurations that will improve estimates of key processes affected by tides, such as Antarctic ice shelf melt rates, ocean warming and the ocean's overturning circulation. The project is thus anticipated to provide significant benefits in predicting future climate change, sea level rise, coastal erosion and marine heatwaves. Furthermore, it will enable the Australian and global communities to better target conservation and mitigation efforts, and thus reduce the environmental, social and economic impact of climate change.. Scheme: Discovery Projects. Field: 3708 - Oceanography. Lead: Dr Callum Shakespeare

Cost-effective Edge Service Provisioning in the Last Mile of 5G. This project aims to deliver a suite of novel approaches for enabling cost-effective last-mile service provisioning in the 5G mobile edge computing (MEC). This project is the world's first attempt to systematically tackle the critical service provisioning challenges in the last mile where base stations link users to MEC applications. It offers a practical solution for provisioning software vendors' MEC services cost-effectively. This project should drive Australia's 5G transition and innovations, promote its post-COVID economic recovery and resilience by enabling various real-time mobile and IoT applications, e.g., telehealth, remote learning/working, industry 4.0, and ensure its pioneering position in the global 5G research.. Scheme: Discovery Projects. Field: 4605 - Data Management and Data Science. Lead: Prof Qiang He

Mapping & Harnessing Public Mistrust: Constitutional Values Survey 2023-27. Declining public trust is well recognised as a problem of democratic government, including in Australia. However solutions are more elusive, confounded by the reality that mistrust and distrust play not just negative, but positive roles in our existing political and constitutional traditions. This project aims to be the first to comprehensively map the positive values of mistrust in citizen political attitudes and experience, building on previous Constitutional Values Surveys (2008-21) to test new measures of the content of trust including a first-ever longitudinal study of changing trust over time. The results will inform concrete solutions to three key policy reform dilemmas, providing better answers for sustaining public trust overall. . Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Prof Alexander Brown