Grants & Opportunities

Australian clays as raw materials of slow-release phosphate fertiliser. Phosphorus (P) fertiliser input in Australia is a significant problem for its inefficient plant uptake, leaching to natural water bodies and stocking of insoluble P in soil. The project aims to develop activated clays using Australian raw clay minerals to formulate effective slow-release phosphate (P) fertilisers (SRF) and delivery material for P-solubilising bacteria. Composite of these will supply P controllably even amid environmental fluctuations but when a plant needs as it grows. Development of multifunctional, nontoxic and plant growth-driven P fertiliser would benefit improve soil fertility in a sustainable way where efficiency of P input is maximised with a minimised environmental burden.. Scheme: Discovery Projects. Field: 4016 - Materials Engineering. Lead: Prof Ravendra (Ravi) Naidu

The Material Science of Biomimetic Soft Network Composites. Nature combines stiff and strong collagen fibres intertwined within a weak polymer matrix of proteoglycans into soft tissues with outstanding mechanical durability and biological properties. We converge a biomimetic design strategy inspired in the architecture of natural soft tissues and a novel additive manufacturing technology termed melt electrowriting (MEW) to manufacture advanced biomimetic soft network composites (BSNC). The SNCs are composed of a weak polymer matrix and a MEW reinforcing fibrous phase printed at the nanometre scale, containing patterns mimicking the natural tissue architectures. Advanced computational tools are applied for the rational design of the SNC while reducing costs and times associated to experimental work.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Dietmar W. Hutmacher

Reading the sequence of a single molecule of DNA . This project seeks to develop technology capable of accurately reading the sequence of a single DNA molecule for the first time. This is possible by combining state-of-the-art methods in DNA self-assembly, single-molecule fluorescence microscopy and bioelectronics, to overcome fundamental limits in current technologies. The outcome of accurate DNA sequencing at single molecule resolution, promises ground-breaking biological insight from a more fine-grained view of the genetic world, game-changing technologies such as point-of-care genomics and in turn a substantial impact on the rapidly growing multi-billion-dollar DNA sequencing market. . Scheme: Discovery Projects. Field: 5105 - Medical and Biological Physics. Lead: A/Prof Lawrence Lee

Energy-efficient liquid-flow system for electroreduction of carbon dioxide. Concerns about fossil fuel depletion and rising carbon emissions have brought about an urgent demand for carbon dioxide (CO2) capture and utilisation technologies. Facilitated by the mechanism-driven catalyst development and engineering innovation, this project aims to deliver a durable and cost-effective approach to electrochemical transformation of CO2 into the valuable products. The proposed automatic liquid-flow reactor system is expected to enable an energy efficient and practical viable CO2 reduction in benign aqueous electrolytes. The resulting innovations will not only reduce the environmental impact of atmospheric CO2 but also generate highly concentrated industrial feedstocks for the sustainable production of commodity chemicals.. Scheme: Discovery Projects. Field: 4016 - Materials Engineering. Lead: Prof Yijiao Jiang

Hiding in Plain Sight: 'Associated Entities' and Australian Democracy. Associated Entities (AEs) are organisations that are formally linked to political parties. This project aims to examine how AEs interact with Australian democracy by investigating their impact on elections, the law, and party system dynamics. This project expects to generate new knowledge about the impact of these nearly 200 key political actors, with a particular focus on how they are able to elude significant scrutiny of their activities. Expected outcomes include a new typology of AEs, a new financial index to measure their impact, and proposals to improve their regulation. The key benefits generated include: a strengthened campaign finance regime, and enhanced transparency and integrity to Australia's democracy.. Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Dr Rob Manwaring

The Role of Lck/CD8 Association in Negatively Regulating T cell Activation. This proposal aims to advance our fundamental understanding of how T cell recognition of antigens translates into a T cell activating signal. The proposal will establish whether the major T cell coreceptor also acts as a negative regulator of T cell activation in vivo when antigen recognition is unorthodox. It will also determine whether certain subsets of T cells naturally lack coreceptors in order to facilitate unorthodox antigen recognition. Thus, the proposal will significantly advance our understanding of, and establish new paradigms around, the regulation of T cell activation. Expected long term benefits outside the scope of this proposal include improved immunotherapies and vaccines designed to elicit or suppress T cell responses.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Nicole La Gruta

A next-generation whole parasite bovine Babesia vaccine. . In Australia, Babesia parasites cause most of the severe and often fatal cases of cattle-tick fever, a globally significant tick-borne disease. It can be prevented by a live-attenuated parasite vaccine which has critical limitations of a 4-day shelf-life and risk of severe disease if administered to adult cattle. This project aims to evaluate in cattle a novel whole parasite Babesia bovis vaccine that cannot cause disease and can be preserved as an off-the-shelf product without losing efficacy. The expected outcome is a significantly improved vaccine for a major infectious disease that affects primary food production. As the disease imposes a major economic burden, it will have great benefit for the Australian livestock industry. . Scheme: Discovery Projects. Field: 3003 - Animal Production. Lead: A/Prof Danielle Stanisic

Resilient design of energy pile foundations toward zero carbon buildings. This project aims to investigate the complex thermo-hydro mechanical interactions affecting the effectiveness of energy pile foundations for improved energy efficiency of new buildings. Using cutting-edge micro to field-scale methods, this project expects to underpin the development of experimentally validated predictions of the geotechnical performance of energy piles. Expected outcomes of this project are the establishment of new approaches to improve the resilient design of energy pile foundations, provision of new recommendations for their design and increased integration for zero carbon buildings. These outcomes will contribute significantly toward strategies to decarbonise energy systems in buildings to meet carbon neutrality goals.. Scheme: Discovery Projects. Field: 4005 - Civil Engineering. Lead: Prof Abdelmalek Bouazza

Transforming Australian bio-based industries through multiscale modelling. Agricultural and forestry biomass can be converted into feedstocks for production of biofuels and biomaterials via synthetic biology. A key challenge is the complex biomass microstructure renders it highly resistant to conversion, and pretreatment is crucial for enhancing process efficiency. Micro-CT imaging will enable particle characterisation and identification of changes in the fibre composition during pretreatment. This information will be used to create a virtual biomass particle model for an in silico investigation to inform optimal process design. The framework will transform the way biomass is processed, contributing to the growth of the Australian bio-manufacturing industry by making it more productive, profitable and sustainable.. Scheme: Discovery Projects. Field: 4903 - Numerical and Computational Mathematics. Lead: Em/Prof Ian Turner

The viral fusosome: a modular machinery for cargo delivery to target cells. The delivery of proteins, RNA and DNA into cells is a critical process in normal cellular biology, virus infection and biotechnology applications such as gene editing. Enveloped viruses achieve this maneuver with exquisite efficiency and specificity using a complex machinery mediating their fusion with cellular membranes for stealth genome delivery. Remarkably, all characterised viral fusion proteins belong to only 3 classes defined >16 years ago and sharing surprisingly conserved mechanisms. We identified a novel class of fusion proteins with unique architecture in ubiquitous insect viruses. The Project will elucidate the structural and functional hallmarks of this fusion machinery providing a platform for its engineering.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Fasseli Coulibaly

Connecting ocean tides to the large-scale ocean circulation. This project aims to investigate the impact of tides on the ocean circulation and future climate change by combining new theory with next-generation numerical ocean models. The expected outcomes include ocean model configurations that will improve estimates of key processes affected by tides, such as Antarctic ice shelf melt rates, ocean warming and the ocean's overturning circulation. The project is thus anticipated to provide significant benefits in predicting future climate change, sea level rise, coastal erosion and marine heatwaves. Furthermore, it will enable the Australian and global communities to better target conservation and mitigation efforts, and thus reduce the environmental, social and economic impact of climate change.. Scheme: Discovery Projects. Field: 3708 - Oceanography. Lead: Dr Callum Shakespeare

Mapping & Harnessing Public Mistrust: Constitutional Values Survey 2023-27. Declining public trust is well recognised as a problem of democratic government, including in Australia. However solutions are more elusive, confounded by the reality that mistrust and distrust play not just negative, but positive roles in our existing political and constitutional traditions. This project aims to be the first to comprehensively map the positive values of mistrust in citizen political attitudes and experience, building on previous Constitutional Values Surveys (2008-21) to test new measures of the content of trust including a first-ever longitudinal study of changing trust over time. The results will inform concrete solutions to three key policy reform dilemmas, providing better answers for sustaining public trust overall. . Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Prof Alexander Brown

Veteran suicide: investigating the historical and social dimensions . This project aims to address veteran suicide by conducting an historical and cultural analysis of the ways government, the military and the community have understood, governed, and serviced veterans from 1914-present. This project will generate new knowledge, moving beyond orthodox medical and cultural assessments to explore wider historical, cultural and sociological relations of veteran suicide, including civil military relations, and the influence of the veteran sector and families and community. The project will develop an innovative survey that will form the foundation of a longitudinal social health and wellbeing dataset on veterans, and contribute to policy and service provision to reduce veteran suicide and improve their wellbeing.. Scheme: Discovery Projects. Field: 4410 - Sociology. Lead: Prof Ben Wadham

Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that provide these novel materials with clear potential as electroactive materials with applications in various nanoelectronics devices. Developing a fundamental understanding of charge transport properties and potential device applications will open up a new field of research in advanced optoelectronic technology. . Scheme: Discovery Projects. Field: 4016 - Materials Engineering. Lead: Prof Prashant Sonar

Dynamic Microcages for Cells: Advanced Tools to Interrogate Cell Mechanics. This project aims to develop a suite of movable micro/nanostructures with integrated mechanical and biological sensors, which will be interfaced with cells to investigate how those cells respond to their surrounding physical environment. Expected outcomes are new technologies in micro/nanofabrication, sensing, and advanced imaging, and deep understanding of the biological processes that control tissue formation and repair. These outcomes would impact how 3D microsystems are developed and applied, informing the design of advanced in-vitro cell culture systems. Significant benefits are expected in 3D nano-microengineering, and in generating new knowledge underpinning future advances in stem cell and tissue engineering technologies.. Scheme: Discovery Projects. Field: 4018 - Nanotechnology. Lead: Prof Nicolas Voelcker

A platform technology for developing mesoporous polymer particles. This project aims to apply polymerisation-induced self-assembly process to develop triggerable mesoporous polymer particles as advanced functional materials for various applications. By combining this scalable process and automated synthesis technique, mesoporous polymer particles that can disassemble in response to external triggers, such as light, redox conditions and enzymes, will be developed. The knowledge gained from this research will allow researchers to fully understand the formation and evolution mechanism of inverse bicontinuous structures observed in nature and produced in synthetic labs. Importantly, the applications of these novel stimuli-responsive particles as nano-carriers and templating scaffolds will be investigated.. Scheme: Discovery Projects. Field: 3403 - Macromolecular and Materials Chemistry. Lead: Prof San Thang

Political Representation in Indonesia. The project aims to understand political representation in Indonesia, asking how far politicians resemble voters in both their policy views and backgrounds (gender, religion, education etc.) It will generate new knowledge on a major potential source of fragility in the world’s third largest democracy, and pioneer a new multi-method approach for explaining how representation varies. Expected outcomes include a new framework that extends analysis of representation to illiberal democracies, and a tranche of public data on Indonesia for cross-national comparisons. Benefits will include a new set of analytical tools to help policy makers in Australia and the region assess sources of weakness in representative institutions in illiberal settings.. Scheme: Discovery Projects. Field: 4408 - Political Science. Lead: Prof Edward Aspinall

The Benefits of Utilising Visual-Spatial Representations of Numbers . The aim of this project is to investigate how visual-spatial representations of numbers enhance practice to promote the use of retrieval-based over counting-based strategies for children learning early arithmetic. About one-third of Australian children stay reliant on counting strategies for basic arithmetic, despite these being associated with lower achievement in mathematics in later years. Expected outcomes of this project are new understandings of how problem-answer associations can be strengthened in memory and the development of tools to promote retrieval-based strategies. Potential benefits include children who are better prepared to take on higher-level mathematics in secondary school and, subsequently, more numerate citizens. . Scheme: Discovery Projects. Field: 3904 - Specialist Studies In Education. Lead: A/Prof Sarah Hopkins

Understanding bone structure evolution using machine learning. Bone remodeling is the ancient process of bone resorption and formation that optimises material properties and has led to evolution of terrestrial vertebrates. To date it is not understood how remodeling achieves tuning of bone material. This proposal aims to develop a machine learning based approach, linking computational modeling and imaging to address this problem. Intended outcomes are development of a multiscale model of remodeling and machine learning algorithms for image analysis. This approach will help establish a structural-functional link between remodeling and bone material optimisation which ultimately provides significant benefits for bone tissue engineering, fracture healing and improved therapies for osteoporosis. . Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Peter Pivonka

Building A Better Built Environment for Older Australian's Ageing-in-place. Most older Australians prefer to age in place after their retirement. This project aims to understand how the built environment as a comprehensive system supports (or hinders) their ageing-in-place given that the existing Australian built environment fails to meet older Australians' requirements for independent living. This project expects to generate new knowledge in the area of ageing-friendly communities using Bayesian Network analysis and interactive design charrettes. Expected outcomes include an evidence-based Bayesian network model that determines how the built environment affects independent living in the community and design innovation and guidelines to improve the built environment design for older Australians' ageing-in-place.. Scheme: Discovery Projects. Field: 3302 - Building. Lead: Prof Bo Xia

Exploiting Geometries of Learning for Fast, Adaptive and Robust AI. This project aims to uniquely exploit geometric manifolds in deep learning to advance the frontier of Artificial Intelligence (AI) research and applications in cybersecurity and general cognitive tasks. It expects to develop new theories, algorithms, tools, and technologies for machine learning systems that are fast, adaptive, lifelong and robust, even with limited supervision. Expected outcomes will enhance Australia's capability and competitiveness in AI, and deliver robust and trustworthy learning technology. The project should provide significant benefits not only in advancing scientific and translational knowledge but also in accelerating AI innovations, safeguarding cyberspace, and reducing the burden on defence expenses in Australia.. Scheme: Discovery Projects. Field: 4611 - Machine Learning. Lead: Prof Dinh Phung

Global integration of microbial community and climate data. Microbial communities in the environment control the cycling of carbon and nutrients on Earth, but climate models do not directly incorporate microbial inputs. This interdisciplinary project will link planetary-scale climate modelling data with novel large-scale microbial community analysis, using climate information to provide insight into the fantastic diversity of microbial processes on our planet. The interdisciplinary approach will inform the next generation of climate models and better predict our future climate’s feedbacks. Conversely, it will make progress on the grand challenge of understanding microbial community function by enabling microbial ecology to be treated as a data-intensive machine learning problem.. Scheme: Discovery Projects. Field: 3107 - Microbiology. Lead: A/Prof Benjamin Woodcroft

The first English speakers in their own words. This project aims to produce the first comprehensive study of the attitudes in the earliest English literature. The project expects to generate new knowledge about the first English speakers, what issues mattered most to them and how broad the range of attitudes was. Expected outcomes of this project include new approaches to studying the past, enhanced international collaborations and a public access to the project's data through an open access digital resource. This should provide significant benefits in terms of our understanding of the past and how it shapes attitudes in contemporary Australia. . Scheme: Discovery Projects. Field: 4705 - Literary Studies. Lead: A/Prof Erin Sebo

Efficient and secure data integrity auditing on cloud. Data auditing presents a promising way for verifying user data integrity on cloud, i.e., whether user privacy sensitive data such as identity information on cloud is modified or lost. Current auditing approaches lack sufficient efficiency and security. This results in that they cannot provide timely warning and precaution on potential data loss threats. This project aims to systematically investigate this significant challenge and expects to establish innovative research and solutions for enabling efficient and secure data integrity auditing on cloud. The project outcomes will help to safeguard Australian community in fast-growing cyber world, and benefit to fast-growing user privacy sensitive data hosting and applications on cloud.. Scheme: Discovery Projects. Field: 4604 - Cybersecurity and Privacy. Lead: Prof Jinjun Chen

Tackling Crystal Methamphetamine Supply in Rural and Regional Australia. This project tackles one of the leading drug policy and organised crime issues in Australia, namely the increased availability of crystal methamphetamine (ice) in rural and regional communities. The first study of its kind nationally, it will use an innovative combination of qualitative and quantitative methods across six communities in three states to uncover how ice infiltrates regional communities, the drivers and mechanisms and impacts thereof. Expected outcomes include a roadmap to reduce supply and harms, strengthened communities and enhanced international collaborations. With ice use and supply costing the Australian government $5 billion per year, the project stands to provide significant social, public health and economic benefits.. Scheme: Discovery Projects. Field: 4402 - Criminology. Lead: A/Prof Caitlin Hughes