Understanding structure, dynamics and function of receptor splice variants. This project aims to understand the functional role of a specific class of G protein-coupled receptors by leveraging advance

Description

Understanding structure, dynamics and function of receptor splice variants. This project aims to understand the functional role of a specific class of G protein-coupled receptors by leveraging advanced cryo-electron microscopy, mass spectrometry, and computational approaches. This project will address fundamental knowledge gaps of how different isoforms of the receptor affect its signalling behaviour. Examining the shape and conformational dynamics of receptor isoforms provides a richer understanding of their cellular function. The comprehensive structural and functional data will allow us to produce molecular movies to better communicate the dynamic receptor activation process. This should provide significant benefits to the Australian community by visualising receptor isoforms with altered physiological function.. Scheme: Discovery Early Career Researcher Award. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Sarah Piper