Using telomeres to study how DNA repair guides cell death and growth arrest. This project examines biological activities influenced by the homologous recombination (HR) DNA repair pathway. In addition

Description

Using telomeres to study how DNA repair guides cell death and growth arrest. This project examines biological activities influenced by the homologous recombination (HR) DNA repair pathway. In addition to DNA repair, we discovered that HR also controls cell death, cell cycle arrest, and interferon signalling following genome damage. These are novel HR functions and how they are regulated is entirely unknown. Here we will use cutting edge imaging techniques, whole genome CRISPR screening, mass spectrometry, and cell and molecular biology to study these newly identified activities. Expected outcomes include a mechanistic understanding of how HR regulates cell death and growth arrest, new perspectives on the diverse biology functions influenced by DNA repair, and training of the next generation of scientists. . Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Anthony Cesare