Discovery of high affinity cyclic glycopeptides via GlycoRaPID mRNA display. This project aims to develop an efficient method for screening large peptide libraries with glycan modifications against ca

Description

Discovery of high affinity cyclic glycopeptides via GlycoRaPID mRNA display. This project aims to develop an efficient method for screening large peptide libraries with glycan modifications against carbohydrate-binding proteins called lectins. Using initiator tRNA and a new click chemistry technique for site-specific glycosylation, I will create diverse peptide libraries with defined glycan modifications. The method developed by the project will be validated by testing on specific lectins to find high-affinity glycosylated peptide ligands. This innovative approach overcomes longstanding challenges in ribosomal glycan incorporation, facilitating the discovery of a new class of molecules for medicinal chemistry applications. The project has the potential to boost Australia's pharmaceutical and biotechnology sectors.. Scheme: Discovery Early Career Researcher Award. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: Dr Yichen (Jessica) Zhong