Dynamic Presentation of Physical Cues to Engineer Aging Models . The lack of suitable aging models is a major roadblock to unravelling the fundamental mechanisms driving human aging. Thus, we aim to e

Description

Dynamic Presentation of Physical Cues to Engineer Aging Models . The lack of suitable aging models is a major roadblock to unravelling the fundamental mechanisms driving human aging. Thus, we aim to engineer physiologically relevant in vitro aging models ie aging in a dish. We will focus on physical properties (structure and mechanical stiffness), which will be programmed to undergo temporal changes at varying resolutions, magnitudes, and time scales. We anticipate novel reproducible models that will recapitulate the dynamic microenvironmental changes in physical properties during the aging process. These aging models will generate new knowledge including novel cellular aging mechanisms by decoupling matrix composition and physical properties, as well as methods to track cellular phenotypic changes. . Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: Prof Khoon Lim