Hippo signalling - from cell membranes to the nucleus. This project aims to use cutting-edge microscopy techniques to define how the Hippo pathway relays signals from the cell surface to the nucleus.

Description

Hippo signalling - from cell membranes to the nucleus. This project aims to use cutting-edge microscopy techniques to define how the Hippo pathway relays signals from the cell surface to the nucleus. Hippo is an ancient signalling pathway and key regulator of organ size, but we have a poor understanding of how it relays messages in cells and thus activity. This project expects to deliver important insights into how the Hippo pathway controls cell fate and organ size, which are essential features of life. Expected outcomes include optimised methods to assess cell signalling in vivo and new collaborations. This should provide significant benefits such as creation of jobs, new knowledge on fundamental principles of life and stimulation of new research into cell signalling and organ size control.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Kieran Harvey