Discovering how nerve cells resist mechanical forces. This project aims to discover the molecular mechanisms protecting nerve cells from mechanical force. Using C. elegans as a tractable model system,

Description

Discovering how nerve cells resist mechanical forces. This project aims to discover the molecular mechanisms protecting nerve cells from mechanical force. Using C. elegans as a tractable model system, combined with state-of-the-art microscopy and sophisticated genome engineering approaches, the project aims to advance our knowledge of how these fragile cells resist the forces imparted on them during development and body movement. Outcomes include a mechanistic understanding of how tissues co-operate to withstand physical strain, the molecules involved and how force is buffered by the nervous system. This will provide significant benefits by generating fundamental knowledge, informing technological advances, and increasing research capacity.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Dr Sean Coakley