An investigation into metabolite-mediated immunity. This project aims to investigate how the immune system is modulated by metabolites, an emerging and key area of the life sciences. Presently, little

Description

An investigation into metabolite-mediated immunity. This project aims to investigate how the immune system is modulated by metabolites, an emerging and key area of the life sciences. Presently, little is known about metabolite-mediated immunity, thereby representing a major knowledge gap. The project aims to combine mass spectrometry, structural and biochemical approaches to learn how metabolites are (i) presented by an antigen presenting molecule called MR1 (ii) how this leads to activation by specific T lymphocytes. Outcomes will significantly advance current understanding of the molecular basis underpinning metabolite-mediated immunity. Major benefits will include fundamental new knowledge about immunity that may ultimately be used by the biotechnology industry.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Jamie Rossjohn