A novel signalling effector of ASC pyroptosomes. The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but

Description

A novel signalling effector of ASC pyroptosomes. The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to validate a new signal effector that induces cell death. Expected outcomes include new insights into how cells die, and how they instruct immune responses from beyond the grave. Project benefits include new fundamental understanding of cell death mechanisms and how this sculpts tissue immune responses, and new knowledge of how to manipulate cell death responses for future basic research and commercial applications beyond this project.. Scheme: Discovery Projects. Field: 3204 - Immunology. Lead: Prof Kate Schroder