Mitochondrial apoptosis signals more than death in innate immune cells. This project will investigate how mitochondrial cell death is triggered in innate immune cells to microbial threats and the down

Description

Mitochondrial apoptosis signals more than death in innate immune cells. This project will investigate how mitochondrial cell death is triggered in innate immune cells to microbial threats and the downstream molecular and cellular events that control the immune response. This project is expected to generate new knowledge surrounding how mitochondria respond to environmental threats using advanced genetic, molecular and cell biology approaches. Expected outcomes include an enhanced understanding of cell death signalling networks, advances in cell biology research methods and new interdisciplinary collaborations. This should provide significant benefits to our basic understanding of how mitochondria shape immune responses and identify ways to manipulate cell death for future research and commercial applications.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: A/Prof Kate Lawlor