Nucleic Acid-Based Molecular Circuitry to Control Biological Processes. Via cutting-edge organic chemical synthesis, this DECRA project aims to develop new molecular circuitries for use in biosensing

Description

Nucleic Acid-Based Molecular Circuitry to Control Biological Processes. Via cutting-edge organic chemical synthesis, this DECRA project aims to develop new molecular circuitries for use in biosensing and control. These will be based on the programmable recognition of synthetic nucleic acids and new applications of established chemical reactions that allow for the release of functional molecules only when desired. Two new circuitry modules will be developed and tested - the first a cleavable nucleic acid scaffold for precise light-dependent uncaging, and the second a novel proximity-mediated release system for tissues inaccessible to light. Benefits for Australia span applications in biotech (real-time molecular sensing), fundamental biology and drug development (targeted drug delivery). . Scheme: Discovery Early Career Researcher Award. Field: 3404 - Medicinal and Biomolecular Chemistry. Lead: Dr Emma Watson