Inter-organ communication during exercise and aging. This project aims to examine how organisms exchange biological material between tissues to promote healthy aging. Extracellular vesicles (EVs), lip

Description

Inter-organ communication during exercise and aging. This project aims to examine how organisms exchange biological material between tissues to promote healthy aging. Extracellular vesicles (EVs), lipid bilayer-delimited particles released from cells, facilitate inter-organ communication of molecular cargo. EVs can promote cellular senescence that can increase with aging. Conversely, exercise can enrich EVs with inhibitors of cellular senescence, thereby slowing the aging process. This is dependent upon the molecular cargo, cellular origin and tissue destination of the EVs, processes completely unknown at present. We expect to discover the mechanisms of action of EVs in exercise and aging, thereby generate new information to develop strategies impacting upon Australia’s ageing workforce. . Scheme: Discovery Projects. Field: 3208 - Medical Physiology. Lead: Prof Mark Febbraio