Combining biomechanics and biomarkers to establish brain injury thresholds. This project aims to define biomechanical thresholds for brain injury, overcoming limitations of prior efforts reliant on pe

Description

Combining biomechanics and biomarkers to establish brain injury thresholds. This project aims to define biomechanical thresholds for brain injury, overcoming limitations of prior efforts reliant on peak acceleration metrics and controlled lab tests that fail to capture the complexity of brain tissue mechanics. By integrating head kinematic data from instrumented mouthguards, MRI-based finite element modelling of brain strain, and brain injury-specific blood biomarkers, this project seeks to link mechanical strain with biological responses. Expected outcomes include identifying strain thresholds derived from wearable sensor data, facilitating timely detection of high-risk impacts. This approach promises significant benefits, enhancing injury detection and informing helmet design for sports, military, and transport.. Scheme: Discovery Projects. Field: 4207 - Sports Science and Exercise. Lead: A/Prof Stuart McDonald