Deciphering the role of granzyme K in immune and organismal aging. This project seeks to elucidate the role of granzyme K, a serine protease markedly elevated in aged T cells, in driving immune and or

Description

Deciphering the role of granzyme K in immune and organismal aging. This project seeks to elucidate the role of granzyme K, a serine protease markedly elevated in aged T cells, in driving immune and organismal aging. Leveraging a well-established colony of aged granzyme K knockout mice, a multidisciplinary network of collaborators, and extensive expertise in studying immune and organismal function both in vitro and in vivo, this research aims to uncover whether this 'hallmark of aging' actively contributes to the biological aging process. The anticipated outcomes include a deeper understanding of: (i) the mechanisms underlying aging, (ii) the connection between immune aging and organismal decline, and (iii) potential therapeutic avenues to reprogram or rejuvenate the biological decline that occurs with age.. Scheme: Discovery Projects. Field: 3202 - Clinical Sciences. Lead: Prof Nicole La Gruta