Androgen Imprinting: Novel Mechanism Linking Minipuberty and Muscle Memory . This project aims to test the hypothesis that the neonatal androgen surge in male mice creates androgen imprinting, a laten

Description

Androgen Imprinting: Novel Mechanism Linking Minipuberty and Muscle Memory . This project aims to test the hypothesis that the neonatal androgen surge in male mice creates androgen imprinting, a latent muscle memory mechanism that enhances functional responses to later stimuli (exercise, androgen). Verifying latent androgen imprinting will expand current knowledge of physiological androgen mechanisms in mammals, viewed now as immediate responses of androgen target tissues like muscle, brain and liver in health and disease. These experiments will decisively test the hypothesis of neonatal androgen imprinting in murine muscle, quantifying its magnitude and durability. Through deeper insight into androgen mechanisms in health and disease, this project will create new opportunities for understanding and intervention.. Scheme: Discovery Projects. Field: 3202 - Clinical Sciences. Lead: Prof David Handelsman