New polar and radical reactions via electron poor alkyne organocatalysis. Organocatalysts are small organic molecules able to catalyse chemical reactions. In contrast to metal or enzyme catalysts they

Description

New polar and radical reactions via electron poor alkyne organocatalysis. Organocatalysts are small organic molecules able to catalyse chemical reactions. In contrast to metal or enzyme catalysts they are simpler to prepare, more robust, and cheaper. However, their use has largely focused on reactions at the carbonyl group (studies which led to the 2021 Nobel prize). In this proposal organocatalysts, either working alone or in tandem, are used to uncover new reactions of alkynes conjugated to the carbonyl group. The reactions targeted are all new and involve polar (2-electron) and/or radical (1-electron) bond formation, along with control of three dimensional shape (stereochemistry). The studies are focused on uncovering general reactivity patterns applicable in a range of contexts.. Scheme: Discovery Projects. Field: 3405 - Organic Chemistry. Lead: Prof David Lupton