Hierarchical nanostructure effects on Nanoparticle-M Cell Interactions. This project aims to develop new design rules for advanced nanoparticle-based oral delivery systems targeting Microfold (M) cell

Description

Hierarchical nanostructure effects on Nanoparticle-M Cell Interactions. This project aims to develop new design rules for advanced nanoparticle-based oral delivery systems targeting Microfold (M) cells in the gut, vital for efficient antigen transport. We will explore how nanoparticles' structures influence M cell interactions, focusing on transcytosis, differentiation, maturation, and enhancing mucosal immunity. Expected outcomes include innovative nanomaterials with specialized surface features tailored for M cell targeting, and fundamental knowledge into nano-mucosa interactions. This advancement promises to revolutionize oral vaccine delivery, offering substantial benefits in both the pharmaceutical and veterinary fields by improving vaccine efficacy and equitable access across diverse economic regions.. Scheme: Discovery Projects. Field: 3214 - Pharmacology and Pharmaceutical Sciences. Lead: Dr Jie Tang