Simple one pot bioconjugation using a novel molecular glue. Nanoparticle, polymer, protein and nucleic acid conjugation is critical for the fields of biosensing, synthetic biology, and drug delivery.

Description

Simple one pot bioconjugation using a novel molecular glue. Nanoparticle, polymer, protein and nucleic acid conjugation is critical for the fields of biosensing, synthetic biology, and drug delivery. However, most current bioconjugation techniques require chemical modification of biomolecules. This is costly, synthetically challenging, and can impair biological function. In this project, we will develop a family of proteins that act as molecular glue, allowing polymers, proteins, nucleic acids, and nanomaterials to be linked without the need to chemically alter the biomolecules. We will demonstrate the power of our novel conjugation technique by synthesising targeted nanoparticles, that are loaded with DNA and sensors that will allow us to quantify subcellular delivery of cargo.. Scheme: Discovery Projects. Field: 4003 - Biomedical Engineering. Lead: A/Prof Angus Johnston