Self-assembled supramolecular cages for guest binding and catalysis. This project aims to construct a family of supramolecular metal-containing cage-shaped molecules that possess specialised binding p

Description

Self-assembled supramolecular cages for guest binding and catalysis. This project aims to construct a family of supramolecular metal-containing cage-shaped molecules that possess specialised binding pockets with unique chemical properties that mimic enzymes. Many existing cage molecules contain well-defined three dimensional cavities reminiscent of enzymes' active sites. However, unlike natural systems they do not contain "active" metals with free coordination sites, and this limits their catalytic ability. This project aims to prepare a large family of robust organic cages quickly and easily, and subsequently incorporate metals containing free active sites that point into the cage cavity. It is expected that this will deliver strong and selective guest binding, and efficient and selective catalysis.. Scheme: Discovery Projects. Field: 3403 - Macromolecular and Materials Chemistry. Lead: A/Prof Nicholas White