Are histones or transcription factors the codemasters in gene regulation? All organisms switch thousands of genes on and off in a precisely orchestrated manner, but through mechanisms that are still m

Description

Are histones or transcription factors the codemasters in gene regulation? All organisms switch thousands of genes on and off in a precisely orchestrated manner, but through mechanisms that are still mysterious in many ways. This project aims to redefine our understanding of the regulation of gene expression in complex organisms by defining the molecular choreography executed by three essential classes of proteins working in concert. The project will leverage our recent discoveries and use advanced approaches in cellular, molecular and structural biology to challenge existing dogma. The outcome will be a deeper understanding of a process conserved over hundreds of millions of years, which will significantly benefit future efforts to modulate gene activity in fields such as agriculture and medicine.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof Joel Mackay