Understanding the interplay between chromatin architecture and DNA repair. Chromatin architecture is crucial for many biological processes, the most well described being transcriptional regulation; ho

Description

Understanding the interplay between chromatin architecture and DNA repair. Chromatin architecture is crucial for many biological processes, the most well described being transcriptional regulation; however, the interplay between 3D chromatin organisation and DNA repair pathway engagement remains to be characterised. The overarching aim of this project is to investigate how chromatin architecture regulates DNA repair. We will focus on the role ATR-activating proteins play in recruiting the nucleosome remodelling and deacetylase (NuRD) chromatin remodelling complex to promote long-range chromatin interactions and homologous recombination (HR)-mediated repair. This project will create new knowledge of how DNA repair pathways are activated, and characterise a level of DNA repair regulation not previously comprehended.. Scheme: Discovery Projects. Field: 3105 - Genetics. Lead: Prof Hilda Pickett