Revealing the Virosphere using Metagenomics and Artificial Intelligence. Our knowledge of the global virosphere is biased and fragmentary. This project will combine metatranscriptomic sequencing with

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Revealing the Virosphere using Metagenomics and Artificial Intelligence. Our knowledge of the global virosphere is biased and fragmentary. This project will combine metatranscriptomic sequencing with artificial intelligence (AI) to reveal the hidden diversity of RNA viruses, the origins of key virus proteins, and the major mechanisms of virus genome evolution. AI protein structural prediction will identify highly divergent RNA virus capsid and envelope proteins. The origins of virus proteins and the patterns and mechanisms of virus genome evolution will be determined through AI predictions of protein foldomes in major groups of RNA viruses. A new diversity of RNA viruses and protein structures will be revealed by the metatranscriptomic sequencing of marine and freshwater sediments sampled throughout Australia.. Scheme: Discovery Projects. Field: 3107 - Microbiology. Lead: Prof Edward Holmes