How does RNA regulate gene repression? RNA is known to have diverse roles in many areas of biology. Currently, however, the mechanisms that link RNA to gene repression are poorly understood. This proj

Description

How does RNA regulate gene repression? RNA is known to have diverse roles in many areas of biology. Currently, however, the mechanisms that link RNA to gene repression are poorly understood. This project aims to address this fundamental knowledge gap by studying how RNA regulates genomic structure at repressed genes. This project will generate new knowledge in the areas of RNA biology and epigenetics through an interdisciplinary approach to combine cutting edge genomics methods with innovative structural biology techniques. Expected outcomes include the development of new methods to study nuclear RNA as well as a more comprehensive picture of the diverse mechanisms governing gene repression. This will significantly benefit our understanding of basic RNA and chromatin biology.. Scheme: Discovery Early Career Researcher Award. Field: 3105 - Genetics. Lead: Dr Evan Healy