Understanding how neural circuit activity is controlled by adenosine. The aim of this project is to understand how adenosine regulates neural circuit activity in spinal networks. Adenosine is a buildi

Description

Understanding how neural circuit activity is controlled by adenosine. The aim of this project is to understand how adenosine regulates neural circuit activity in spinal networks. Adenosine is a building block of life and essential for energy metabolism, but also functions as a signalling molecule. In this role, it has been studied extensively in the heart, but there has been less focus on neuronal signalling in sensory pathways. This project will focus on adenosine A1-receptor signalling to address this gap in the field by revealing the source of adenosine in this region, the effects of A1 receptor activation from the level of a single neuron, up to the network of sensory neurons regulated by adenosine. Lastly, we will develop new tools that can be used to understand adenosine signalling in multiple systems.. Scheme: Discovery Projects. Field: 3209 - Neurosciences. Lead: A/Prof Wendy Imlach