In situ discoveries at the immune synapse. Immune cells form synapses to kill malignant and pathogen infected cells. The formation of the immunological synapse is underpinned by a complex array of bio

Description

In situ discoveries at the immune synapse. Immune cells form synapses to kill malignant and pathogen infected cells. The formation of the immunological synapse is underpinned by a complex array of biological macromolecules that collectively influence immune and target cell destiny. To understand the organisation of molecules within immune synapse we need to directly visualise the immune synapse in situ and in sufficient detail to identify the major protein components. To achieve this we will use cryogenic electron tomography and proteomics to identify and understand the spatial arrangement of key molecules present in the synapse. The work will provide new and long-sought after insights into an immunity-related process that is required for life.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: Prof James Whisstock