Unveiling Myeloid Cells as Regulators of Nerve Innervation in Tissue Repair. The mechanisms that regulate peripheral tissue healing are not yet fully understood. My recent research, published in Natur

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Unveiling Myeloid Cells as Regulators of Nerve Innervation in Tissue Repair. The mechanisms that regulate peripheral tissue healing are not yet fully understood. My recent research, published in Nature in 2024, discovered that a neuro-immune axis plays a critical role in controlling skin and muscle healing in normal mice after injury. I found that nociceptor sensory nerve endings grow and infiltrate the tissue injury site and release neuropeptides, promoting tissue repair by locally regulating immune cells. These findings underscore the importance of nociceptor activation in skin and muscle healing. In this proposal, I aim to investigate how nociceptors are initially activated and regulated in injured skin and muscle, and how these mechanisms contribute to the regulation of tissue healing.. Scheme: Discovery Early Career Researcher Award. Field: 3206 - Medical Biotechnology. Lead: Dr Yen-Zhen Lu