On-target mRNA technology using self-splicing introns. Emerging mRNA technologies are strongly limited by the lack of target-specific delivery systems which is a major obstacle to their broader applic

Description

On-target mRNA technology using self-splicing introns. Emerging mRNA technologies are strongly limited by the lack of target-specific delivery systems which is a major obstacle to their broader application. The aim of this proposal is to develop a novel type of mRNA technology that relies on target-sensitive self-splicing introns inserted into the mRNA cargo. This technology should provide specificity by selective activation of its mRNA cargo in target cells, tissues or organisms, instead of relying on targeted delivery systems. The expected outcome of the project is the proof-of-concept of this novel approach. This should drastically expand the potential applications of mRNA technologies and further cement Australia’s position as a leader in mRNA innovation.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: A/Prof Tamas Fischer