Revealing hidden membrane protein regulation via electrostatic switches. Aims: 1) Discover mechanisms of ion pump regulation based on electrical lipid-protein interactions; 2) Discover the role of lip

Description

Revealing hidden membrane protein regulation via electrostatic switches. Aims: 1) Discover mechanisms of ion pump regulation based on electrical lipid-protein interactions; 2) Discover the role of lipid asymmetry in determining ion pump activity. Significance: 1) Provide deeper understanding of membrane biophysics; 2) Provide knowledge of the function of an unresolved region of ion pump structures. Expected outcomes: 1) Identification of the effects of membrane interaction of ion pumps on their structure, function, and mechanism; 2) Pinpointing of the amino acids and lipids responsible for membrane interaction; 3) Isolation of the regulatory mechanisms involved in the membrane interaction of ion pumps. Benefits: Refocussing of ion pump research on the surrounding membrane.. Scheme: Discovery Projects. Field: 3101 - Biochemistry and Cell Biology. Lead: A/Prof Ronald Clarke