An investigation into T cell immunity towards metabolites. This project aims to investigate how the immune system responds to small molecule metabolites, an emerging area in the life sciences about w

Description

An investigation into T cell immunity towards metabolites. This project aims to investigate how the immune system responds to small molecule metabolites, an emerging area in the life sciences about which little is known. The project aims to combine innovative mass spectrometry, structural and biochemical approaches to learn how metabolites are presented to specific T lymphocytes by an antigen presenting molecule called MR1. Outcomes are expected to transform the current understanding of the molecular basis underpinning metabolite-mediated immunity. Significant benefits are anticipated to include fundamental new knowledge about immunity that may ultimately be used by the biotechnology industry.. Scheme: Discovery Projects. Field: 0601 - Biochemistry and Cell Biology. Lead: Prof Jamie Rossjohn